I played Bioshock 1 on hard but with vitas enabled. I actually don’t like the vita chambers that much I always thought they were a device to make the game easier for players having a hard time fighting the bosses. There are no “check points” so you do have to manually save and if you play on hard you are going to want to do so quite a bit. To a degree it does take you out of the game saving section to section or before a big fight but I like playing that way for some reason. Again for most people I would suggest to just play on Normal with everything on. The main draw of the game is the story and not making it “hard” but I’m a narcissist in many ways.